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Mitofusin-Dependent ER Stress Triggers Glial Dysfunction and Nervous System Degeneration in a Drosophila Model of Friedreich’s Ataxia

Friedreich’s ataxia (FRDA) is the most important recessive ataxia in the Caucasian population. It is caused by a deficit of the mitochondrial protein frataxin. Despite its pivotal effect on biosynthesis of iron-sulfur clusters and mitochondrial energy production, little is known about the influence...

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Foilsithe in:Front Mol Neurosci
Main Authors: Edenharter, Oliver, Schneuwly, Stephan, Navarro, Juan A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5845754/
https://ncbi.nlm.nih.gov/pubmed/29563863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00038
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