Next-Generation Sequencing Analysis of the Human TCRγδ+ T-Cell Repertoire Reveals Shifts in Vγ- and Vδ-Usage in Memory Populations upon Aging

Immunological aging remodels the immune system at several levels. This has been documented in particular for the T-cell receptor (TCR)αβ+ T-cell compartment, showing reduced naive T-cell outputs and an accumulation of terminally differentiated clonally expanding effector T-cells, leading to increase...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Kallemeijn, Martine J., Kavelaars, François G., van der Klift, Michèle Y., Wolvers-Tettero, Ingrid L. M., Valk, Peter J. M., van Dongen, Jacques J. M., Langerak, Anton W.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5845707/
https://ncbi.nlm.nih.gov/pubmed/29559980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00448
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