Dysregulated signaling, proliferation and apoptosis impact on the pathogenesis of TCRγδ+ T cell large granular lymphocyte leukemia

TCRγδ+ T-LGL leukemia is a rare form of chronic mature T cell disorders in elderly, which is generally characterized by a persistently enlarged CD3+CD57+TCRγδ+ large granular lymphocyte population in the peripheral blood with a monoclonal phenotype. Clinically, the disease is heterogeneous, most pat...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kallemeijn, Martine J., de Ridder, Dick, Schilperoord-Vermeulen, Joyce, van der Klift, Michèle Y., Sandberg, Yorick, van Dongen, Jacques J. M., Langerak, Anton W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391076/
https://ncbi.nlm.nih.gov/pubmed/28407008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0175670
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