Lack of common TCRA and TCRB clonotypes in CD8(+)/TCRαβ(+) T-cell large granular lymphocyte leukemia: a review on the role of antigenic selection in the immunopathogenesis of CD8(+) T-LGL

Clonal CD8(+)/T-cell receptor (TCR)αβ(+) T-cell large granular lymphocyte (T-LGL) proliferations constitute the most common subtype of T-LGL leukemia. Although the etiology of T-LGL leukemia is largely unknown, it has been hypothesized that chronic antigenic stimulation contributes to the pathogenes...

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Main Authors: Sandberg, Y, Kallemeijn, M J, Dik, W A, Tielemans, D, Wolvers-Tettero, I L M, van Gastel-Mol, E J, Szczepanski, T, Pol, Y, Darzentas, N, van Dongen, J J M, Langerak, A W
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3913939/
https://ncbi.nlm.nih.gov/pubmed/24413066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2013.70
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