Pharmacodynamic and pharmacokinetic effects and safety of verinurad in combination with allopurinol in adults with gout: a phase IIa, open-label study

OBJECTIVES: Verinurad (RDEA3170) is a high affinity, selective uric acid transporter (URAT1) inhibitor indevelopment for treating gout and asymptomatic hyperuricaemia. This phase IIa study evaluated the pharmacodynamics, pharmacokinetics and safety of verinurad combined with allopurinol versus allop...

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Dettagli Bibliografici
Pubblicato in:RMD Open
Autori principali: Fleischmann, Roy, Winkle, Peter, Miner, Jeffrey N, Yan, Xiaohong, Hicks, Liz, Valdez, Shakti, Hall, Jesse, Liu, Sha, Shen, Zancong, Gillen, Michael, Hernandez-Illas, Martha
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Publishing Group 2018
Soggetti:
Crystal Arthropathies
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5845419/
https://ncbi.nlm.nih.gov/pubmed/29531784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/rmdopen-2017-000584
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