Pharmacodynamic and pharmacokinetic effects and safety of verinurad in combination with febuxostat in adults with gout: a phase IIa, open-label study

OBJECTIVE: Verinurad (RDEA3170) is a high-affinity, selective URAT1 inhibitor in development for treating gout and asymptomatic hyperuricaemia. This study evaluated the pharmacodynamics, pharmacokinetics and safety of verinurad in combination with febuxostat in adults with gout. METHODS: The phase I...

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Publicado en:RMD Open
Autores principales: Fleischmann, Roy, Winkle, Peter, Hall, Jesse, Valdez, Shakti, Liu, Sha, Yan, Xiaohong, Hicks, Liz, Lee, Caroline, Miner, Jeffrey N, Gillen, Michael, Hernandez-Illas, Martha
Formato: Artigo
Lenguaje:Inglês
Publicado: BMJ Publishing Group 2018
Materias:
Crystal Arthropathies
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5892780/
https://ncbi.nlm.nih.gov/pubmed/29657831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/rmdopen-2018-000647
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