A Negative Allosteric Modulator of PDE4D Enhances Learning after Traumatic Brain Injury

Traumatic brain injury (TBI) significantly decreases cyclic AMP (cAMP) signaling which produces long-term synaptic plasticity deficits and chronic learning and memory impairments. Phosphodiesterase 4 (PDE4) is a major family of cAMP hydrolyzing enzymes in the brain and of the four PDE4 subtypes, PDE...

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Publicat a:Neurobiol Learn Mem
Autors principals: Titus, David J., Wilson, Nicole M., Alcazar, Oscar, Calixte, Dale A., Dietrich, W. Dalton, Gurney, Mark E., Atkins, Coleen M.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844849/
https://ncbi.nlm.nih.gov/pubmed/29294383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nlm.2017.12.008
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