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A Negative Allosteric Modulator of PDE4D Enhances Learning after Traumatic Brain Injury
Traumatic brain injury (TBI) significantly decreases cyclic AMP (cAMP) signaling which produces long-term synaptic plasticity deficits and chronic learning and memory impairments. Phosphodiesterase 4 (PDE4) is a major family of cAMP hydrolyzing enzymes in the brain and of the four PDE4 subtypes, PDE...
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| Publicado no: | Neurobiol Learn Mem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5844849/ https://ncbi.nlm.nih.gov/pubmed/29294383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nlm.2017.12.008 |
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