High-Content Surface and Total Expression siRNA Kinase Library Screen with VX-809 Treatment Reveals Kinase Targets that Enhance F508del-CFTR Rescue

[Image: see text] The most promising F508del-CFTR corrector, VX-809, has been unsuccessful as an effective, stand-alone treatment for CF patients, but the rescue effect in combination with other drugs may confer an acceptable level of therapeutic benefit. Targeting cellular factors that modify traff...

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Detalhes bibliográficos
Publicado no:Mol Pharm
Main Authors: Perkins, Lydia A., Fisher, Gregory W., Naganbabu, Matharishwan, Schmidt, Brigitte F., Mun, Frederick, Bruchez, Marcel P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844356/
https://ncbi.nlm.nih.gov/pubmed/29384380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.7b00928
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