Deletion of a Long-Range Dlx5 Enhancer Disrupts Inner Ear Development in Mice

Distal enhancers are thought to play important roles in the spatiotemporal regulation of gene expression during embryonic development, but few predicted enhancer elements have been shown to affect transcription of their endogenous genes or to alter phenotypes when disrupted. Here, we demonstrate tha...

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Vydáno v:Genetics
Hlavní autoři: Johnson, Kenneth R., Gagnon, Leona H., Tian, Cong, Longo-Guess, Chantal M., Low, Benjamin E., Wiles, Michael V., Kiernan, Amy E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Genetics Society of America 2018
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Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844329/
https://ncbi.nlm.nih.gov/pubmed/29301908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.117.300447
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