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Deletion of a Long-Range Dlx5 Enhancer Disrupts Inner Ear Development in Mice

Distal enhancers are thought to play important roles in the spatiotemporal regulation of gene expression during embryonic development, but few predicted enhancer elements have been shown to affect transcription of their endogenous genes or to alter phenotypes when disrupted. Here, we demonstrate tha...

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Pubblicato in:Genetics
Autori principali: Johnson, Kenneth R., Gagnon, Leona H., Tian, Cong, Longo-Guess, Chantal M., Low, Benjamin E., Wiles, Michael V., Kiernan, Amy E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Genetics Society of America 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844329/
https://ncbi.nlm.nih.gov/pubmed/29301908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.117.300447
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