Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through exosome secretion

Little is known about how leukemia cells alter the bone marrow (BM) niche to facilitate their own growth and evade chemotherapy. Here, we provide evidence that acute myeloid leukemia (AML) blasts remodel the BM niche into a leukemia growth-permissive and normal hematopoiesis-suppressive microenviron...

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Dades bibliogràfiques
Publicat a:Leukemia
Autors principals: Kumar, B, Garcia, M, Weng, L, Jung, X, Murakami, J L, Hu, X, McDonald, T, Lin, A, Kumar, A R, DiGiusto, D L, Stein, A S, Pullarkat, V A, Hui, S K, Carlesso, N, Kuo, Y-H, Bhatia, R, Marcucci, G, Chen, C-C
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2018
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5843902/
https://ncbi.nlm.nih.gov/pubmed/28816238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.259
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