Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through exosome secretion

Little is known about how leukemia cells alter the bone marrow (BM) niche to facilitate their own growth and evade chemotherapy. Here, we provide evidence that acute myeloid leukemia (AML) blasts remodel the BM niche into a leukemia growth-permissive and normal hematopoiesis-suppressive microenviron...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Kumar, B, Garcia, M, Weng, L, Jung, X, Murakami, J L, Hu, X, McDonald, T, Lin, A, Kumar, A R, DiGiusto, D L, Stein, A S, Pullarkat, V A, Hui, S K, Carlesso, N, Kuo, Y-H, Bhatia, R, Marcucci, G, Chen, C-C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2018
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5843902/
https://ncbi.nlm.nih.gov/pubmed/28816238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.259
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