Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through exosome secretion

Little is known about how leukemia cells alter the bone marrow (BM) niche to facilitate their own growth and evade chemotherapy. Here, we provide evidence that acute myeloid leukemia (AML) blasts remodel the BM niche into a leukemia growth-permissive and normal hematopoiesis-suppressive microenviron...

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Veröffentlicht in:Leukemia
Hauptverfasser: Kumar, B, Garcia, M, Weng, L, Jung, X, Murakami, J L, Hu, X, McDonald, T, Lin, A, Kumar, A R, DiGiusto, D L, Stein, A S, Pullarkat, V A, Hui, S K, Carlesso, N, Kuo, Y-H, Bhatia, R, Marcucci, G, Chen, C-C
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2018
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5843902/
https://ncbi.nlm.nih.gov/pubmed/28816238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.259
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