Sustained plasma hepcidin suppression and iron elevation by Anticalin‐derived hepcidin antagonist in cynomolgus monkey

BACKGROUND AND PURPOSE: Anaemia of chronic disease (ACD) has been linked to iron‐restricted erythropoiesis imposed by high circulating levels of hepcidin, a 25 amino acid hepatocyte‐derived peptide that controls systemic iron homeostasis. Here, we report the engineering of the human lipocalin‐derive...

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Publicado en:Br J Pharmacol
Autores principales: Hohlbaum, Andreas M, Gille, Hendrik, Trentmann, Stefan, Kolodziejczyk, Maria, Rattenstetter, Barbara, Laarakkers, Coby M, Katzmann, Galina, Christian, Hans Jürgen, Andersen, Nicole, Allersdorfer, Andrea, Olwill, Shane A, Meibohm, Bernd, Audoly, Laurent P, Swinkels, Dorine W, van Swelm, Rachel P L
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5843705/
https://ncbi.nlm.nih.gov/pubmed/29329501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14143
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