Sustained plasma hepcidin suppression and iron elevation by Anticalin‐derived hepcidin antagonist in cynomolgus monkey

BACKGROUND AND PURPOSE: Anaemia of chronic disease (ACD) has been linked to iron‐restricted erythropoiesis imposed by high circulating levels of hepcidin, a 25 amino acid hepatocyte‐derived peptide that controls systemic iron homeostasis. Here, we report the engineering of the human lipocalin‐derive...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Br J Pharmacol
Prif Awduron: Hohlbaum, Andreas M, Gille, Hendrik, Trentmann, Stefan, Kolodziejczyk, Maria, Rattenstetter, Barbara, Laarakkers, Coby M, Katzmann, Galina, Christian, Hans Jürgen, Andersen, Nicole, Allersdorfer, Andrea, Olwill, Shane A, Meibohm, Bernd, Audoly, Laurent P, Swinkels, Dorine W, van Swelm, Rachel P L
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2018
Pynciau:
Research Papers
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5843705/
https://ncbi.nlm.nih.gov/pubmed/29329501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14143
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