Sustained plasma hepcidin suppression and iron elevation by Anticalin‐derived hepcidin antagonist in cynomolgus monkey

BACKGROUND AND PURPOSE: Anaemia of chronic disease (ACD) has been linked to iron‐restricted erythropoiesis imposed by high circulating levels of hepcidin, a 25 amino acid hepatocyte‐derived peptide that controls systemic iron homeostasis. Here, we report the engineering of the human lipocalin‐derive...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Hohlbaum, Andreas M, Gille, Hendrik, Trentmann, Stefan, Kolodziejczyk, Maria, Rattenstetter, Barbara, Laarakkers, Coby M, Katzmann, Galina, Christian, Hans Jürgen, Andersen, Nicole, Allersdorfer, Andrea, Olwill, Shane A, Meibohm, Bernd, Audoly, Laurent P, Swinkels, Dorine W, van Swelm, Rachel P L
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5843705/
https://ncbi.nlm.nih.gov/pubmed/29329501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14143
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