An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm

Thoracic aortic aneurysm (TAA) has been associated with mutations affecting members of the TGF-β signaling pathway, or components and regulators of the vascular smooth muscle cell (VSMC) actomyosin cytoskeleton. Although both clinical groups present similar phenotypes, the existence of potential com...

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Vydáno v:Nat Commun
Hlavní autoři: Lino Cardenas, Christian L., Kessinger, Chase W., Cheng, Yisha, MacDonald, Carolyn, MacGillivray, Thomas, Ghoshhajra, Brian, Huleihel, Luai, Nuri, Saifar, Yeri, Ashish S., Jaffer, Farouc A., Kaminski, Naftali, Ellinor, Patrick, Weintraub, Neal L., Malhotra, Rajeev, Isselbacher, Eric M., Lindsay, Mark E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5843596/
https://ncbi.nlm.nih.gov/pubmed/29520069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03394-7
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