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Genotoxicity of ortho-quinones: reactive oxygen species versus covalent modification

o-Quinones are formed metabolically from natural and synthetic estrogens as well as upon exposure to polycyclic aromatic hydrocarbons (PAH) and contribute to estrogen and PAH carcinogenesis by genotoxic mechanisms. These mechanisms include the production of reactive oxygen species to produce DNA str...

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Detalhes bibliográficos
Publicado no:Toxicol Res (Camb)
Autor principal: Penning, Trevor M.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5842949/
https://ncbi.nlm.nih.gov/pubmed/29527287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7tx00223h
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