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PAH o-quinones produced by the Aldo-Keto-Reductases (AKRs) generate abasic sites, oxidized pyrimidines and 8-oxo-dGuo via reactive oxygen species

Reactive and redox-active polycyclic aromatic hydrocarbon (PAH) o-quinones produced by Aldo-Keto Reductases (AKRs) have the potential to cause depurinating adducts leading to the formation of abasic sites and oxidative base lesions. The aldehyde reactive probe (ARP) was used to detect these lesions...

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書誌詳細
主要な著者: Park, Jong-Heum, Troxel, Andrea B., Harvey, Ronald G., Penning, Trevor M.
フォーマット: Artigo
言語:Inglês
出版事項: 2006
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2366214/
https://ncbi.nlm.nih.gov/pubmed/16696575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx0600245
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