The Autophagy-Related Beclin-1 Protein Requires the Coiled-Coil and BARA Domains To Form a Homodimer with Submicromolar Affinity

Beclin-1 (BECN1) is an essential component of macroautophagy. This process is a highly conserved survival mechanism that recycles damaged cellular components or pathogens by encasing them in a bilayer vesicle that fuses with a lysosome to allow degradation of the vesicular contents. Mutations or alt...

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Udgivet i:Biochemistry
Main Authors: Ranaghan, Matthew J., Durney, Michael A., Mesleh, Michael F., McCarren, Patrick R., Garvie, Colin W., Daniels, Douglas S., Carey, Kimberly L., Skepner, Adam P., Levine, Beth, Perez, Jose R.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5842915/
https://ncbi.nlm.nih.gov/pubmed/29185708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00936
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