Targeted co-delivery of Beclin 1 siRNA and FTY720 to hepatocellular carcinoma by calcium phosphate nanoparticles for enhanced anticancer efficacy

PURPOSE: FTY720, known as fingolimod, is a new immunosuppressive agent with effective anticancer properties. Although it was recently confirmed that FTY720 inhibits cancer cell proliferation, FTY720 can also induce protective autophagy and reduce cytotoxicity. Blocking autophagy with Beclin 1 siRNA...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Wu, Jun-Yi, Wang, Zhong-Xia, Zhang, Guang, Lu, Xian, Qiang, Guang-Hui, Hu, Wei, Ji, An-Lai, Wu, Jun-Hua, Jiang, Chun-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5842779/
https://ncbi.nlm.nih.gov/pubmed/29551896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S156328
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