The role of the endoplasmic reticulum protein calreticulin in mediating TGF-β-stimulated extracellular matrix production in fibrotic disease

Endoplasmic reticulum (ER) stress is a key factor contributing to fibrotic disease. Although ER stress is a short-term adaptive response, with chronic stimulation, it can activate pathways leading to fibrosis. ER stress can induce TGF-β signaling, a central driver of extracellular matrix production...

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Vydáno v:J Cell Commun Signal
Hlavní autoři: Owusu, Benjamin Y., Zimmerman, Kurt A., Murphy-Ullrich, Joanne E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Netherlands 2017
Témata:
Review
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5842189/
https://ncbi.nlm.nih.gov/pubmed/29080087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12079-017-0426-2
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