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Positive autoregulation and repression of transactivation are key regulatory features of the Candida glabrata Pdr1 transcription factor
Resistance to azole drugs, the major clinical antifungal compounds, is most commonly due to gain-of-function (GOF) substitution mutations in a gene called PDR1 in the fungal pathogen Candida glabrata. PDR1 encodes a zinc cluster-containing transcription factor. GOF forms of Pdr1 drive high level exp...
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| Publicado no: | Mol Microbiol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5842128/ https://ncbi.nlm.nih.gov/pubmed/29363861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.13913 |
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