Selective blockade of CD28 on human T cells facilitates regulation of alloimmune responses

T cells are central to the detrimental alloresponses that develop in autoimmunity and transplantation, with CD28 costimulatory signals being key to T cell activation and proliferation. CTLA4-Ig molecules that bind CD80/86 and inhibit CD28 costimulation offer an alternative immunosuppressive treatmen...

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Detaylı Bibliyografya
Yayımlandı:JCI Insight
Asıl Yazarlar: Zaitsu, Masaaki, Issa, Fadi, Hester, Joanna, Vanhove, Bernard, Wood, Kathryn J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2017
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5841880/
https://ncbi.nlm.nih.gov/pubmed/28978798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.89381
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