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Selective blockade of CD28 on human T cells facilitates regulation of alloimmune responses
T cells are central to the detrimental alloresponses that develop in autoimmunity and transplantation, with CD28 costimulatory signals being key to T cell activation and proliferation. CTLA4-Ig molecules that bind CD80/86 and inhibit CD28 costimulation offer an alternative immunosuppressive treatmen...
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| Publié dans: | JCI Insight |
|---|---|
| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Clinical Investigation
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5841880/ https://ncbi.nlm.nih.gov/pubmed/28978798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.89381 |
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