DOCK8 regulates fitness and function of regulatory T cells through modulation of IL-2 signaling

Foxp3(+) Tregs possess potent immunosuppressive activity, which is critical for maintaining immune homeostasis and self-tolerance. Defects in Treg development or function result in inadvertent immune activation and autoimmunity. Despite recent advances in Treg biology, we still do not completely und...

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Détails bibliographiques
Publié dans:JCI Insight
Auteurs principaux: Singh, Akhilesh K., Eken, Ahmet, Hagin, David, Komal, Khushbu, Bhise, Gauri, Shaji, Azima, Arkatkar, Tanvi, Jackson, Shaun W., Bettelli, Estelle, Torgerson, Troy R., Oukka, Mohamed
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5841873/
https://ncbi.nlm.nih.gov/pubmed/28978795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.94275
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