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DOCK8 regulates fitness and function of regulatory T cells through modulation of IL-2 signaling
Foxp3(+) Tregs possess potent immunosuppressive activity, which is critical for maintaining immune homeostasis and self-tolerance. Defects in Treg development or function result in inadvertent immune activation and autoimmunity. Despite recent advances in Treg biology, we still do not completely und...
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| Wydane w: | JCI Insight |
|---|---|
| Główni autorzy: | , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Clinical Investigation
2017
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5841873/ https://ncbi.nlm.nih.gov/pubmed/28978795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.94275 |
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