DOCK8 regulates fitness and function of regulatory T cells through modulation of IL-2 signaling

Foxp3(+) Tregs possess potent immunosuppressive activity, which is critical for maintaining immune homeostasis and self-tolerance. Defects in Treg development or function result in inadvertent immune activation and autoimmunity. Despite recent advances in Treg biology, we still do not completely und...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:JCI Insight
Hauptverfasser: Singh, Akhilesh K., Eken, Ahmet, Hagin, David, Komal, Khushbu, Bhise, Gauri, Shaji, Azima, Arkatkar, Tanvi, Jackson, Shaun W., Bettelli, Estelle, Torgerson, Troy R., Oukka, Mohamed
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5841873/
https://ncbi.nlm.nih.gov/pubmed/28978795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.94275
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge