Retinal guanylyl cyclase activating protein 1 forms a functional dimer

Retinal guanylyl cyclases (RetGCs) in vertebrate photoreceptors are regulated by the guanylyl cyclase activator proteins (GCAP1 and GCAP2). Here, we report EPR double electron-electron resonance (DEER) studies on the most ubiquitous GCAP isoform, GCAP1 and site-directed mutagenesis analysis to deter...

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Publicat a:PLoS One
Autors principals: Lim, Sunghyuk, Roseman, Graham, Peshenko, Igor, Manchala, Grace, Cudia, Diana, Dizhoor, Alexander M., Millhauser, Glenn, Ames, James B.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5841803/
https://ncbi.nlm.nih.gov/pubmed/29513743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0193947
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