Using biomarkers to predict TB treatment duration (Predict TB): a prospective, randomized, noninferiority, treatment shortening clinical trial

Background: By the early 1980s, tuberculosis treatment was shortened from 24 to 6 months, maintaining relapse rates of 1-2%. Subsequent trials attempting shorter durations have failed, with 4-month arms consistently having relapse rates of 15-20%. One trial shortened treatment only among those witho...

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Detalhes bibliográficos
Publicado no:Gates Open Res
Main Authors: Chen, Ray Y., Via, Laura E., Dodd, Lori E., Walzl, Gerhard, Malherbe, Stephanus T., Loxton, André G., Dawson, Rodney, Wilkinson, Robert J., Thienemann, Friedrich, Tameris, Michele, Hatherill, Mark, Diacon, Andreas H., Liu, Xin, Xing, Jin, Jin, Xiaowei, Ma, Zhenya, Pan, Shouguo, Zhang, Guolong, Gao, Qian, Jiang, Qi, Zhu, Hong, Liang, Lili, Duan, Hongfei, Song, Taeksun, Alland, David, Tartakovsky, Michael, Rosenthal, Alex, Whalen, Christopher, Duvenhage, Michael, Cai, Ying, Goldfeder, Lisa C., Arora, Kriti, Smith, Bronwyn, Winter, Jill, Barry III, Clifton E.
Formato: Artigo
Idioma:Inglês
Publicado em: F1000 Research Limited 2017
Assuntos:
Study Protocol
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5841574/
https://ncbi.nlm.nih.gov/pubmed/29528048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/gatesopenres.12750.1
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