121. Improving Predictive Value of Phase 2a TB Drug Development Models Through PET/CT Imaging (NexGen EBA)

BACKGROUND: Current Phase 2a methods in tuberculosis (TB) drug development are severely limited in capturing a drug candidate’s sterilizing activity (ability to prevent TB relapse). We hypothesize that sputum-based measurements of current methods fail to capture drug activity in deep TB lesion compa...

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Published in:Open Forum Infect Dis
Main Authors: Xie, Yingda, Via, Laura, Chen, Ray, Dodd, Lori, Cai, Ying, Paripati, Paveen, Goldfeder, Lisa, Winter, Jill, Arora, Kriti, Wang, Jing, De Jagar, Veronique, Malherbe, Stephanus, Song, Taeksun, Walzl, Gerhard, Diacon, Andreas, III, Clifton Barry
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6252863/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofy209.012
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