Mycobacterium fortuitum-induced ER-Mitochondrial calcium dynamics promotes calpain/caspase-12/caspase-9 mediated apoptosis in fish macrophages

Mycobacterium fortuitum is a natural fish pathogen. It induces apoptosis in headkidney macrophages (HKM) of catfish, Clarias sp though the mechanism remains largely unknown. We observed M. fortuitum triggers calcium (Ca(2+)) insult in the sub-cellular compartments which elicits pro-apototic ER-stres...

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Publicat a:Cell Death Discov
Autors principals: Datta, Debika, Khatri, Preeti, Singh, Ambika, Saha, Dhira Rani, Verma, Gaurav, Raman, Rajagopal, Mazumder, Shibnath
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5841318/
https://ncbi.nlm.nih.gov/pubmed/29531827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-018-0034-9
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