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TLR-2 mediated cytosolic-Ca(2+) surge activates ER-stress-superoxide-NO signalosome augmenting TNF-α production leading to apoptosis of Mycobacterium smegmatis-infected fish macrophages
The implications of TLR-2 mediated alterations in cytosolic-Ca(2+)((Ca(2+))(c)) levels in M. smegmatis infections is not well known. Using headkidney macrophages (HKM) from Clarias gariepinus, we observed TLR-2 signalling is required in the phagocytosis of M. smegmatis. M. smegmatis induced caspase-...
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| Publié dans: | Sci Rep |
|---|---|
| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6707155/ https://ncbi.nlm.nih.gov/pubmed/31444398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48847-1 |
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