Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer’s disease mice

The Dlg4 gene encodes for post-synaptic density protein 95 (PSD95), a major synaptic protein that clusters glutamate receptors and is critical for plasticity. PSD95 levels are diminished in ageing and neurodegenerative disorders, including Alzheimer’s disease and Huntington’s disease. The epigenetic...

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發表在:Brain
Main Authors: Bustos, Fernando J, Ampuero, Estibaliz, Jury, Nur, Aguilar, Rodrigo, Falahi, Fahimeh, Toledo, Jorge, Ahumada, Juan, Lata, Jaclyn, Cubillos, Paula, Henríquez, Berta, Guerra, Miguel V, Stehberg, Jimmy, Neve, Rachael L, Inestrosa, Nibaldo C, Wyneken, Ursula, Fuenzalida, Marco, Härtel, Steffen, Sena-Esteves, Miguel, Varela-Nallar, Lorena, Rots, Marianne G, Montecino, Martin, van Zundert, Brigitte
格式: Artigo
語言:Inglês
出版: Oxford University Press 2017
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Original Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5841035/
https://ncbi.nlm.nih.gov/pubmed/29155979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awx272
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