Genome-wide analysis yields new loci associating with aortic valve stenosis

Aortic valve stenosis (AS) is the most common valvular heart disease, and valve replacement is the only definitive treatment. Here we report a large genome-wide association (GWA) study of 2,457 Icelandic AS cases and 349,342 controls with a follow-up in up to 4,850 cases and 451,731 controls of Euro...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Helgadottir, Anna, Thorleifsson, Gudmar, Gretarsdottir, Solveig, Stefansson, Olafur A., Tragante, Vinicius, Thorolfsdottir, Rosa B., Jonsdottir, Ingileif, Bjornsson, Thorsteinn, Steinthorsdottir, Valgerdur, Verweij, Niek, Nielsen, Jonas B., Zhou, Wei, Folkersen, Lasse, Martinsson, Andreas, Heydarpour, Mahyar, Prakash, Siddharth, Oskarsson, Gylfi, Gudbjartsson, Tomas, Geirsson, Arnar, Olafsson, Isleifur, Sigurdsson, Emil L., Almgren, Peter, Melander, Olle, Franco-Cereceda, Anders, Hamsten, Anders, Fritsche, Lars, Lin, Maoxuan, Yang, Bo, Hornsby, Whitney, Guo, Dongchuan, Brummett, Chad M., Abecasis, Gonçalo, Mathis, Michael, Milewicz, Dianna, Body, Simon C., Eriksson, Per, Willer, Cristen J., Hveem, Kristian, Newton-Cheh, Christopher, Smith, J. Gustav, Danielsen, Ragnar, Thorgeirsson, Gudmundur, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F., Holm, Hilma, Stefansson, Kari
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5840367/
https://ncbi.nlm.nih.gov/pubmed/29511194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03252-6
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