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Single-cell RNA sequencing reveals developmental heterogeneity of blastomeres during major genome activation in bovine embryos

Embryonic development is initially controlled by maternal RNAs and proteins stored in the oocyte, until gene products gradually generated by the embryo itself take over. Major embryonic genome activation (EGA) in bovine embryos occurs at the eight- to 16-cell stage. Morphological observations, such...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Lavagi, Ilaria, Krebs, Stefan, Simmet, Kilian, Beck, Andrea, Zakhartchenko, Valeri, Wolf, Eckhard, Blum, Helmut
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5840315/
https://ncbi.nlm.nih.gov/pubmed/29511234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22248-2
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