Pericyte degeneration causes white matter dysfunction in the mouse CNS

Diffuse white matter disease associated with small vessel disease and dementia is prevalent in the elderly. The biological mechanisms, however, remain elusive. Using pericyte-deficient mice, magnetic resonance imaging, viral-based tract-tracing, behavior and tissue analysis, here we show that pericy...

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Publicado en:Nat Med
Autores principales: Montagne, Axel, Nikolakopoulou, Angeliki M., Zhao, Zhen, Sagare, Abhay P., Si, Gabriel, Lazic, Divna, Barnes, Samuel R., Daianu, Madelaine, Ramanathan, Anita, Go, Ariel, Lawson, Erica J., Wang, Yaoming, Mack, William J., Thompson, Paul M., Schneider, Julie A., Varkey, Jobin, Langen, Ralf, Mullins, Eric, Jacobs, Russell E., Zlokovic, Berislav V.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5840035/
https://ncbi.nlm.nih.gov/pubmed/29400711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4482
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