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Many helper T cell subsets have Fas ligand-dependent cytotoxic potential

CD4(+) helper T cells can have cytotoxic activity against cells displaying relevant peptide-MHCII (p:MHCII) ligands. Cytotoxicity may be a property of Th1 cells and depend on perforin and the Eomes transcription factor. We assessed these assertions for polyclonal p:MHCII-specific CD4(+) T cells acti...

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Bibliografske podrobnosti
izdano v:J Immunol
Main Authors: Kotov, Dmitri I., Kotov, Jessica A., Goldberg, Michael F., Jenkins, Marc K.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5840022/
https://ncbi.nlm.nih.gov/pubmed/29436413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700420
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