DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune cell activation

Immunotherapy offers new cancer treatment options, but efficacy varies across cancer types. Colorectal cancers (CRCs) are largely refractory to immune checkpoint blockade, suggesting the presence of yet-to-be characterized immune suppressive mechanisms. Here we report that APC-loss in intestinal tum...

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Publicado no:Nat Med
Main Authors: Xiao, Qian, Wu, Jibo, Wang, Wei-Jia, Chen, Shiyang, Zheng, Yingxia, Yu, Xiaoqing, Meeth, Katrina, Sahraei, Mahnaz, Bothwell, Alfred L. M., Chen, Lieping, Bosenberg, Marcus, Chen, Jianfeng, Sexl, Veronika, Sun, Le, Li, Lin, Tang, Wenwen, Wu, Dianqing
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5840007/
https://ncbi.nlm.nih.gov/pubmed/29431745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4496
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