2′-O-methylation in mRNA disrupts tRNA decoding during translation elongation

Chemical modifications of messenger RNA (mRNA) may regulate many aspects of mRNA processing and protein synthesis. Recently, 2′-O-methylation of nucleotides was identified as a frequent modification in translated regions of human mRNA, showing enrichment in codons for certain amino acid. Here, using...

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Detaylı Bibliyografya
Yayımlandı:Nat Struct Mol Biol
Asıl Yazarlar: Choi, Junhong, Indrisiunaite, Gabriele, DeMirci, Hasan, Ieong, Ka-Weng, Wang, Jinfan, Petrov, Alexey, Prabhakar, Arjun, Rechavi, Gideon, Dominissini, Dan, He, Chuan, Ehrenberg, Måns, Puglisi, Joseph D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5840002/
https://ncbi.nlm.nih.gov/pubmed/29459784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-018-0030-z
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