2′-O-methylation in mRNA disrupts tRNA decoding during translation elongation

Chemical modifications of messenger RNA (mRNA) may regulate many aspects of mRNA processing and protein synthesis. Recently, 2′-O-methylation of nucleotides was identified as a frequent modification in translated regions of human mRNA, showing enrichment in codons for certain amino acid. Here, using...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Nat Struct Mol Biol
Main Authors: Choi, Junhong, Indrisiunaite, Gabriele, DeMirci, Hasan, Ieong, Ka-Weng, Wang, Jinfan, Petrov, Alexey, Prabhakar, Arjun, Rechavi, Gideon, Dominissini, Dan, He, Chuan, Ehrenberg, Måns, Puglisi, Joseph D.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5840002/
https://ncbi.nlm.nih.gov/pubmed/29459784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-018-0030-z
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki