N(6)-methyladenosine in mRNA disrupts tRNA selection and translation elongation dynamics

N(6)-methylation of adenosine (m6A) is the most abundant post-transcriptional modification within the coding region of mRNA, but its role during translation remains unknown. Here, we used bulk kinetic and single-molecule methods to probe the effect of m6A in mRNA decoding. Although m6A base pairs wi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Struct Mol Biol
Prif Awduron: Choi, Junhong, Ieong, Ka-Weng, Demirci, Hasan, Chen, Jin, Petrov, Alexey, Prabhakar, Arjun, O'Leary, Seán E., Dominissini, Dan, Rechavi, Gideon, Soltis, S. Michael, Ehrenberg, Måns, Puglisi, Joseph D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826618/
https://ncbi.nlm.nih.gov/pubmed/26751643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3148
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