CXCR2 is a negative regulator of p21 in p53-dependent and independent manner via Akt-mediated Mdm2 in ovarian cancer

Ovarian cancer (OC) has the highest rate of mortality among gynecological malignancy. Chemokine receptor CXCR2 in OC is associated with poor outcomes. However, the mechanisms by which CXCR2 regulates OC proliferation remain poorly understood. We generated CXCR2-positive cells from parental p53 wild-...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Ignacio, Rosa Mistica C., Dong, Yuan-Lin, Kabir, Syeda M., Choi, Hyeongjwa, Lee, Eun-Sook, Wilson, Andrew J., Beeghly-Fadiel, Alicia, Whalen, Margaret M., Son, Deok-Soo
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839399/
https://ncbi.nlm.nih.gov/pubmed/29515768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24231
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