Targeting the RhoA-ROCK Pathway to Reverse T Cell Dysfunction in SLE

OBJECTIVES: Deregulated production of IL-17 and IL-21 contributes to the pathogenesis of autoimmune disorders like SLE and RA. Production of IL-17 and IL-21 can be regulated by ROCK2, one of the two Rho kinases. Increased ROCK activation was previously observed in an SLE cohort. Here, we evaluated R...

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Bibliografiske detaljer
Udgivet i:Ann Rheum Dis
Main Authors: Rozo, Cristina, Chinenov, Yurii, Maharaj, Reena Khianey, Gupta, Sanjay, Leuenberger, Laura, Kirou, Kyriakos A., Bykerk, Vivian P., Goodman, Susan M., Salmon, Jane E., Pernis, Alessandra B.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839171/
https://ncbi.nlm.nih.gov/pubmed/28283529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2016-209850
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