Composition and Function of Mutant Swi/Snf Complexes

The 12 subunit Swi/Snf chromatin remodeling complex is conserved from yeast to humans. It functions to alter nucleosome positions by either sliding nucleosomes on DNA or evicting histones. Interestingly, 20% of all human cancers carry mutations in subunits of the Swi/Snf complex. Many of these mutat...

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Foilsithe in:Cell Rep
Main Authors: Dutta, Arnob, Sardiu, Mihaela, Gogol, Madelaine, Gilmore, Joshua, Zhang, Daoyong, Florens, Laurence, Abmayr, Susan M., Washburn, Michael P., Workman, Jerry L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837817/
https://ncbi.nlm.nih.gov/pubmed/28249159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.01.058
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