Architecture of the human mTORC2 core complex

The mammalian target of rapamycin (mTOR) is a key protein kinase controlling cellular metabolism and growth. It is part of the two structurally and functionally distinct multiprotein complexes mTORC1 and mTORC2. Dysregulation of mTOR occurs in diabetes, cancer and neurological disease. We report the...

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Pubblicato in:eLife
Autori principali: Stuttfeld, Edward, Aylett, Christopher HS, Imseng, Stefan, Boehringer, Daniel, Scaiola, Alain, Sauer, Evelyn, Hall, Michael N, Maier, Timm, Ban, Nenad
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2018
Soggetti:
Structural Biology and Molecular Biophysics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837792/
https://ncbi.nlm.nih.gov/pubmed/29424687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.33101
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