Architecture of the human mTORC2 core complex

The mammalian target of rapamycin (mTOR) is a key protein kinase controlling cellular metabolism and growth. It is part of the two structurally and functionally distinct multiprotein complexes mTORC1 and mTORC2. Dysregulation of mTOR occurs in diabetes, cancer and neurological disease. We report the...

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Bibliographic Details
Published in:eLife
Main Authors: Stuttfeld, Edward, Aylett, Christopher HS, Imseng, Stefan, Boehringer, Daniel, Scaiola, Alain, Sauer, Evelyn, Hall, Michael N, Maier, Timm, Ban, Nenad
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2018
Subjects:
Structural Biology and Molecular Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837792/
https://ncbi.nlm.nih.gov/pubmed/29424687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.33101
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