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Perturbation to Cholesterol at the Neuromuscular Junction Confers Botulinum Neurotoxin A Sensitivity to Neonatal Mice

Botulinum neurotoxin A (BoNT/A) cleaves SNAP25 at the motor nerve terminals and inhibits stimulus evoked acetylcholine release. This causes skeletal muscle paralysis. However, younger neonatal mice (<P7; <7-days old) are resistant to the neuroparalytic effects of BoNT/A. That is, invivo inject...

詳細記述

保存先:
書誌詳細
出版年:Toxicol Sci
主要な著者: Thyagarajan, Baskaran, Potian, Joseph G., McArdle, Joseph J., Baskaran, Padmamalini
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837569/
https://ncbi.nlm.nih.gov/pubmed/28645175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfx127
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