Perturbation to Cholesterol at the Neuromuscular Junction Confers Botulinum Neurotoxin A Sensitivity to Neonatal Mice

Botulinum neurotoxin A (BoNT/A) cleaves SNAP25 at the motor nerve terminals and inhibits stimulus evoked acetylcholine release. This causes skeletal muscle paralysis. However, younger neonatal mice (<P7; <7-days old) are resistant to the neuroparalytic effects of BoNT/A. That is, invivo inject...

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Detaylı Bibliyografya
Yayımlandı:Toxicol Sci
Asıl Yazarlar: Thyagarajan, Baskaran, Potian, Joseph G., McArdle, Joseph J., Baskaran, Padmamalini
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2017
Konular:
Botulinum Neurotoxin a and Cholesterol at the Neuromuscular Junction
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837569/
https://ncbi.nlm.nih.gov/pubmed/28645175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfx127
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