Fidaxomicin jams Mycobacterium tuberculosis RNA polymerase motions needed for initiation via RbpA contacts

Fidaxomicin (Fdx) is an antimicrobial RNA polymerase (RNAP) inhibitor highly effective against Mycobacterium tuberculosis RNAP in vitro, but clinical use of Fdx is limited to treating Clostridium difficile intestinal infections due to poor absorption. To identify the structural determinants of Fdx b...

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Vydáno v:eLife
Hlavní autoři: Boyaci, Hande, Chen, James, Lilic, Mirjana, Palka, Margaret, Mooney, Rachel Anne, Landick, Robert, Darst, Seth A, Campbell, Elizabeth A
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2018
Témata:
Structural Biology and Molecular Biophysics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837556/
https://ncbi.nlm.nih.gov/pubmed/29480804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.34823
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