Structure and function of the mycobacterial transcription initiation complex with the essential regulator RbpA

RbpA and CarD are essential transcription regulators in mycobacteria. Mechanistic analyses of promoter open complex (RPo) formation establish that RbpA and CarD cooperatively stimulate formation of an intermediate (RP2) leading to RPo; formation of RP2 is likely a bottleneck step at the majority of...

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Bibliographic Details
Published in:eLife
Main Authors: Hubin, Elizabeth A, Fay, Allison, Xu, Catherine, Bean, James M, Saecker, Ruth M, Glickman, Michael S, Darst, Seth A, Campbell, Elizabeth A
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2017
Subjects:
Biochemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302886/
https://ncbi.nlm.nih.gov/pubmed/28067618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.22520
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